Part:BBa_K4610003

The part BBa_K4610003 is the DNA segment Afu8g00390. It encodes for the protein O-methyltransferase af390-400/Fumagillin biosynthesis methyltransferase (Fma-MT). After Fma-MT is synthesized, it’s used in the Fumagillin biosynthesis pathway to cause the methylation of 5-keto-demethoxy fumagillol. 5-keto-demethoxyfumagillol is hydroxylated by the dioxygenase Fma-C6H (BBa_K4610002) and then methylated by Fma-MT (BBa_K4610003), which is a polyketide transferase. The hydroxylation and methylation in the C6 position of 5-keto-demethoxyfumagillol yields 5-keto-fumagillol and the pathway continues (Guruceaga et. al 2020).